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Why is the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine in its diphosphorylated form (PMEApp(4-)) initially a better substrate for polymerases than (2 '-deoxy)adenosine 5 '-triphosphate (dATP(4-)/ATP(4-))? Considerations on the mechanism of nucleic acid polymerases

  1. TitleWhy is the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine in its diphosphorylated form (PMEApp(4-)) initially a better substrate for polymerases than (2 '-deoxy)adenosine 5 '-triphosphate (dATP(4-)/ATP(4-))? Considerations on the mechanism of nucleic acid polymerases
    Author infoHelmut Sigel ... [et al.]
    Author Sigel Helmut (20%)
    Co-authors Song Bin (16%)
    Blindauer Claudia A. (16%)
    Kapinos Larisa E. (16%)
    Gregáň Fridrich 1944- (16%) UMBFP08 - Katedra chémie
    Prónayová Nadja (16%)
    Source document Chemical Communications. No. 8 (1999), pp. 743-744. - Cambridge : The Royal Society of Chemistry, 1999
    Keywords metal ion complexes   aqueous solution   derivatives   hydrolysis  
    LanguageEnglish
    CountryGreat Britian
    systematics 54
    Public work category ADC
    No. of Archival Copy26159
    Repercussion category EVANS, Bradley S. - ZHAO, Changming - GAO, Jiangtao et al. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. In ACS chemical biology. ISSN 1554-8929, 2013, vol. 8, no. 5, pp. 908-913.
    GUO, Y.H. - GE, Q.C. - LIN, H.K. et al. The role of copper(II) ion in regulating H-bonding and coulombic interactions in copper(II)/tripod/polyphosphate systems. In Transition metal chemistry. ISSN 0340-4285, 2003, vol. 28, no. 6, pp. 609-615.
    Catal.org.BB301 - Univerzitná knižnica Univerzity Mateja Bela v Banskej Bystrici
    Databasexpca - PUBLIKAČNÁ ČINNOSŤ
    ReferencesPERIODIKÁ-Súborný záznam periodika
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Number of the records: 1  

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