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Synthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines

  1. TitleSynthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines
    Author infoFrantišek Šeršeň ... [et al.]
    Author Šeršeň František (15%)
    Co-authors Gregáň Fridrich 1944- (15%) UMBFP08 - Katedra chémie
    Kotora Peter (10%)
    Kmeťová Jarmila 1975- (20%) UMBFP08 - Katedra chémie
    Filo Juraj (10%)
    Loos Dušan (5%)
    Gregáň Juraj (25%)
    Source document Molecules. Vol. 22, no. 6 (2017), pp. 1-11. - Basel : Multidisciplinary Digital Publishing Institute, 2017
    Keywords electrons   derivatives  
    LanguageEnglish
    CountrySwitzerland
    systematics 54
    AnnotationHydroxybenzylidene hydrazines exhibit a wide spectrum of biological activities. Here, we report synthesis and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N'-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures of these compounds were confirmed by H-1-NMR, C-13-NMR, F-19-NMR, IR spectroscopy, LC-MS, and elemental analysis. The prepared compounds were tested for their activity to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR), and 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The free radical scavenging activity expressed as SC50 values of these compounds varied in a wide range, from a strong to no radical scavenging effect. The most effective radical scavengers were hydroxybenzylidene hydrazines containing three hydroxyl groups in the benzylidene part of their molecules. The prepared compounds were also tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts. IC50 values of these compounds varied in wide range, from an intermediate to no inhibitory effect.
    Public work category ADC
    No. of Archival Copy40545
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    Catal.org.BB301 - Univerzitná knižnica Univerzity Mateja Bela v Banskej Bystrici
    Databasexpca - PUBLIKAČNÁ ČINNOSŤ
    ReferencesPERIODIKÁ-Súborný záznam periodika
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