Počet záznamov: 1
On the possibility of an early evolutionary origin for the spliced leader trans-splicing
SYS 0250206 005 20240510104721.4 014 $a 000408952900005 $2 CCC 014 $a 000408952900005 $2 WOS CC. SCIE 014 $a 2-s2.0-85025829804 $2 SCOPUS 014 $a BCI201700849293 $2 BIOSIS Citation Index 014 $a 28744787 $2 MEDLINE 014 $a 28744787 $2 PubMed 017 70
$a 10.1007/s00239-017-9803-y $2 DOI 100 $a 20170905 2017 m y slo 03 ba 101 0-
$a eng 102 $a US 200 1-
$a On the possibility of an early evolutionary origin for the spliced leader trans-splicing $f Zuzana Krchňáková, Juraj Krajčovič, Matej Vesteg 330 $a © 2017 Springer Science+Business Media, LLC Trans-splicing is a process by which 5′- and 3′-ends of two pre-RNA molecules transcribed from different sites of the genome can be joined together to form a single RNA molecule. The spliced leader (SL) trans-splicing is mediated by the spliceosome and it allows the replacement of 5′-end of pre-mRNA by 5′(SL)-end of SL-RNA. This form of splicing has been observed in many phylogenetically unrelated eukaryotes. Either the SL trans-splicing (SLTS) originated in the last eukaryotic common ancestor (LECA) (or even earlier) and it was lost in most eukaryotic lineages, or this mechanism of RNA processing evolved several times independently in various unrelated eukaryotic taxa. The bioinformatic comparisons of SL-RNAs from various eukaryotic taxonomic groups have revealed the similarities of secondary structures of most SL-RNAs and a relative conservation of their splice sites (SSs) and Sm-binding sites (SmBSs). We propose that such structural and functional similarities of SL-RNAs are unlikely to have evolved repeatedly many times. Hence, we favor the scenario of an early evolutionary origin for the SLTS and multiple losses of SL-RNAs in various eukaryotic lineages. 463 -1
$1 001 umb_un_cat*0293253 $1 011 $a 0022-2844 $1 011 $a 1432-1432 $1 200 1 $a Journal of Molecular Evolution $v Vol. 85, no. 1-2 (2017), pp. 37-45 $1 210 $a New York $c Springer $d 2017 606 0-
$3 umb_un_auth*0036317 $a biológia $X biology 606 0-
$3 umb_un_auth*0044893 $a evolučná biológia $X evolutionary biology 615 $n 57 $a Biológia 675 $a 57 700 -1
$a Krchňáková $b Zuzana $3 umb_un_auth*0262166 $4 070 $9 40 701 -0
$a Krajčovič $b Juraj $3 umb_un_auth*0031532 $4 070 $9 30 701 -1
$a Vesteg $b Matej $3 umb_un_auth*0255964 $p UMBFP09 $4 070 $9 30 $f 1982- $T Katedra biológie a ekológie 801 -0
$a SK $b BB301 $g AACR2 $9 unimarc sk T85 $x existuji fulltexy
Počet záznamov: 1