Počet záznamov: 1
Euglena gracilis and trypanosomatids possess common patterns in predicted mitochondrial targeting presequences
SYS 0236587 LBL ---naa--22--------450- 005 20240513125454.7 014 $a 000312262600005 $2 WOS CC. SCIE 014 $a 000312262600005 $2 CCC 014 $a 2-s2.0-84872744233 $2 SCOPUS 014 $a BCI201300126900 $2 BIOSIS Citation Index 014 $a 23064754 $2 PubMed 014 $a 23064754 $2 MEDLINE 014 $a ZOOR14906020932 $2 ZR 017 70
$a 10.1007/s00239-012-9523-2 $2 DOI 101 0-
$a eng 200 1-
$a Euglena gracilis and trypanosomatids possess common patterns in predicted mitochondrial targeting presequences $f Katarína Krnáčová ... [et al.] 330 $a Euglena gracilis possessing chloroplasts of secondary green algal origin and parasitic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania major belong to the protist phylum Euglenozoa. Euglenozoa might be among the earliest eukaryotic branches bearing ancestral traits reminiscent of the last eukaryotic common ancestor (LECA) or missing features present in other eukaryotes. LECA most likely possessed mitochondria of endosymbiotic alpha-proteobacterial origin. In this study, we searched for the presence of homologs of mitochondria-targeted proteins from other organisms in the currently available EST dataset of E. gracilis. The common motifs in predicted N-terminal presequences and corresponding homologs from T. brucei, T. cruzi and L. major (if found) were analyzed. Other trypanosomatid mitochondrial protein precursor (e. g., those involved in RNA editing) were also included in the analysis. Mitochondrial presequences of E. gracilis and these trypanosomatids seem to be highly variable in sequence length (5-118 aa), but apparently share statistically significant similarities. In most cases, the common (M/L)RR motif is present at the N-terminus and it is probably responsible for recognition via import apparatus of mitochondrial outer membrane. Interestingly, this motif is present inside the predicted presequence region in some cases. In most presequences, this motif is followed by a hydrophobic region rich in alanine, leucine, and valine. In conclusion, either RR motif or arginine-rich region within hydrophobic aa-s present at the N-terminus of a preprotein can be sufficient signals for mitochondrial import irrespective of presequence length in Euglenozoa. 463 -1
$1 001 umb_un_cat*0293254 $1 011 $a 0022-2844 $1 011 $a 1432-1432 $1 200 1 $a Journal of Molecular Evolution $v Vol. 75, no. 3-4 (2012), pp. 119-129 $1 210 $a New York $c Springer $d 2012 606 0-
$3 umb_un_auth*0256257 $a červenoočká $X Euglenoids $Y Euglenida 606 0-
$3 umb_un_auth*0178658 $a genómy $X genomes 606 0-
$3 umb_un_auth*0256268 $a kinetoplastidy $X kinetoplastids 606 0-
$3 umb_un_auth*0222457 $a molekulárna fylogenetika $X molecular phylogenetics 615 $n 577 $a Biochémia. Molekulárna biológia. Biofyzika 675 $a 577 700 -1
$3 umb_un_auth*0170321 $a Krnáčová $b Katarína $9 40 $4 070 701 -1
$3 umb_un_auth*0255964 $a Vesteg $b Matej $f 1982- $9 30 $4 070 701 -1
$3 umb_un_auth*0255982 $a Hampl $b Vladimír $4 070 $9 5 701 -1
$3 umb_un_auth*0255983 $a Vlček $b Čestmír $4 070 $9 5 701 -1
$3 umb_un_auth*0115250 $a Horváth $b Anton $4 070 $9 20 856 9-
$u http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&UT=WOS:000312262600005 $a Link do databázy WoS T85 $x existuji fulltexy
Počet záznamov: 1