Adverse childhood experiences as a background for alcoholic liver disease - cohort analysis of risk score in ALD and non-ALD cirrhosis patients in comparison with the control group

Šulejová, Karolína ; Symposium of portal hypertension. medzinárodné sympózium (11. : 17.-18.06.2022 : Banská Štiavnica)

Adverse childhood experiences as a background for alcoholic liver disease - cohort analysis of risk score in ALD and non-ALD cirrhosis patients in comparison with the control group / K. K. Šulejová, S. Selčanová Adamcová ... [et al.]. -- The alcoholic liver disease represents the main cause of liver cirrhosis in the Slovak republic. An important position in the development of addiction has childhood trauma. Child abuse, neglect, and other traumatic experiences contribute to the development of risky patterns of behavior leading to the evolution of cirrhosis. The Adverse Childhood Experience Questionnaire is a rating scale evaluating the main risky domains for the development of addiction, and it could play as an indicator for cirrhosis development. In the following period, we evaluated adverse childhood experiences by the 10-item questionnaire in all patients enrolled in the local register of cirrhosis. The endpoint of this study was to assess the risk score for ALD and non- ALD groups in contrast with the cut-off value for the peril of addiction. According to the questionnaire, we tried to analyze the high-risk domain for the development of alcoholic liver disease. Finally, we compared the ACE risk score in ALD, non-ALD, and control groups, which were represented by university students. ACE score in a cohort of patients with alcohol cirrhosis reached 3.21 points (2.88–3.54 points). In comparison, the ACE score in non-ALD cirrhosis was 1,26 points, and in the cohort of university students 1.32 points. The main domains of ACE for ALD were sexual and physical abuse, alcohol addiction, and depression in the family. The higher score in ACE-Q reflects grave childhood trauma which represents the risk for addiction and correlates with the prevalence of ALD-cirrhosis in our local register. We assume that a higher number of points from ACE-Q could predict the development of alcoholic hepatitis and alcoholic cirrhosis and simultaneously could be a useful predictive tool for recurrence of thy abuse after liver transplantation.

In Gastroenterologie a hepatologie : časopis České gastroenterologické společnosti, České hepatologické společnosti, Slovenskej gastroenterologickej spoločnosti a Slovenskej hepatologickej spoločnosti. -- Praha : Česká lékařská společnost Jana Evangelisty Purkyně, 2022. -- ISSN 1804-7874. -- ISSN 1804-803X. -- Roč. 76, č. 3 (2022), s. 174